BIOC 3560 Study Guide - Fall 2018, Comprehensive Midterm Notes - Protein, Oxygen, Hemoglobin

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Hemoglobin (the iron containing protein of vertebrate blood) transports oxygen from the lungs to other parts of the body. Motor proteins are responsible for the undulations of cilia and flagella. Actin and myosin proteins are responsible for the contraction of muscles structural proteins function: support ex. Keratin is the protein of hair, horns, feathers, and other skin appendages. = [l] at which half of the ligand binding sites are occupied. Y = (cid:2912)i(cid:2924)(cid:2914)i(cid:2924)g (cid:2929)i(cid:2930)(cid:2915)(cid:2929) (cid:2925)(cid:2913)(cid:2913)(cid:2931)(cid:2926)i(cid:2915)(cid:2914) (cid:2930)(cid:2925)(cid:2930)(cid:2911)l (cid:2912)i(cid:2924)(cid:2914)i(cid:2924)g (cid:2929)i(cid:2930)(cid:2915)(cid:2929) The fraction of ligand-binding sites occupied, y, is a hyperbolic function of ligand concentration. For o2-binding proteins, we use the following . Y = = (cid:2926)(cid:2899)(cid:2870) (cid:2926)(cid:2899)(cid:2870)+(cid:2900)5(cid:2868) po2 = partial pressure of o2. P50 = partial pressure of o2 in the air above the solution at which half the ligand-binding sites are occupied. Protein conformation is critical for specificity of protein-ligand interaction.

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