BIOC 4580 Study Guide - Midterm Guide: Streptavidin, Atp Hydrolysis, Guanidinium Chloride

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Class 18: proton-induced rotation & binding change mechanism of atp synthesis. The atp synthesis reaction is readily reversible and involves a pentacovalent phosphate intermediate as shown by 18o isotope exchange experiments. The binding change model involves different conformational states for each of the (cid:1007) -subunits. The proton gradient also drives transport systems for the metabolites in a loose complex termed the atp-synthasome. Uncoupling (e. g. , via ucp) of proton motive force from atp synthesis generates heat and occurs in brown adipose tissue. The fofi-atp synthase (atpase) is similar in part to dna helicases and bacterial flagellar rotors, and evolved by modular evolution. = a1b2c8-10-14 ((yeast = 10, bovine = 8/12, spinach = 14) (cid:272) = (cid:862)proteolipid(cid:863) su(cid:271)u(cid:374)it, highl(cid:455) h(cid:455)dropho(cid:271)i(cid:272) Forms a helical hairpin with 2 tm segments and a short connecting loop on the matrix side. Multiple copies of c assemble to form a ring-like structure in the membrane this is the channel through which the h+ flow.

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