BIOC 4580 Study Guide - Midterm Guide: Hereditary Elliptocytosis, Spherocytosis, Dynein

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Vesicles containing cargo or membrane components are shuttled through the cytosol along mf or mt highways with the help of motor proteins such as myosin on mfs, and kinesin & dynein on mts. The associations of cytoskeletal with integral membrane proteins restrict their mobilities & their distribution is consequently non-random. The shape of the prototypical erythrocyte membrane is also maintained dynamically by cytoskeletal proteins, deficiency in which results in diseases such as spherocytosis or elliptocytosis. Associations with plasma or internal membranes are frequent. Spectrin-like proteins are found in cells of the intestinal brush border. Myosins move in both directions along microfilaments (actin) Dyneins & kinesins move in opposite directions along microtubules (tubulin) Neurons have very well-developed cytoskeletal systems for shuttling vesicles back & forth. ** transport of vesicles can be visualized on the giant squid axon. I(cid:374) (cid:374)euro(cid:374)s, (cid:448)esi(cid:272)les & orga(cid:374)elles (cid:373)o(cid:448)e at ~(cid:1005) (cid:373)/da(cid:455) alo(cid:374)g a(cid:454)o(cid:374)al mt (cid:862)tra(cid:272)ks(cid:863) Organelles & vesicles also move inside all other cells this way.

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