Cytoskeleton Comparison Chart

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Published on 27 Apr 2012
Department
Course
Microtubules
Intermediate Filaments
Microfilaments
Components
-tubulin and -tubulin
heterodimers
Heterogeneous proteins
G-actin F-actin
Size
Large (25nm)
Intermediate (10 -12nm)
Small ( 8nm )
Stability
Dynamically Unstable
(Cytoplasmic)
Stable
Dynamically Unstable
Polarity
Polar
- plus end tends to be near the
outside of the cell
Non-polar
Polar
Function
- structural support for the cell
- act as tracks for vesicular
transport
- provide intracellular support
and spatial organization within
the cell
- provide structural support
and mechanical strength to the
cell
- structural support for the cell
- contribute to cell mobility and
motility by pushing out the
leading edge of the cell
(lamellipodium) and pulling in
the trailing edge
- cytokinesis and muscle
contraction
Associated Proteins
- MAPs (both motor and non-
motor)
- non-motor: control
microtubule organization in the
cytosol (Tau in neurons)
- motor: move along the
microtubules and associate with
transport vesicles (kinesin and
dynein)
- MPPs facilitate the
elongation process (profilin)
- FDPs facilitate the
depolymerization process
(cofilin)
- Arp 2/3 facilitates the
nucleation process
- Myosins are the motor
proteins associated with
microfilaments
- must move towards plus end
- unconventional contribute
to cell mobility and motility in
non-muscle cells
- conventional contribute to
muscle contraction
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