BIOL 1090 Study Guide - Ribosomal Rna, 18S Ribosomal Rna, 5.8S Ribosomal Rna

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Nuclear membrane, nuclear pores, nuclear lamina: structure two parallel phospholipid bi-layers separated by 10-50nm, different than other membranes we"ve discussed. Outer membrane binds ribosomes: continuous with rough er intermembrane space continuous with er lumen inner membrane bears integral proteins, which connect to nuclear lamina supported by nuclear lamina. Very solid structure; hard to disrupt; cells can rupture and ne will remain intact: function, separates nuclear content from cytoplasm. Segregates transcription and translation: selective barrier. Allows limited movement of molecules between nucleus and cytoplasm using channel proteins. The nuclear lamina: structure thin meshwork of filamentous proteins next to the nucleoplasmic leaflet of the inner nuclear membrane lamins (class v ifs) Bound to inner membrane of ne by integral membrane proteins. Provides structural support for ne associates with dna; provides attachment sites for chromatin: creates specialized regions of activity, allowing relevant parts of dna to be accessed by transcription machinery . Gateways between cytoplasm and nucleoplasm: allow transport.

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