BIOM 3090 Study Guide - Final Guide: Nicotinic Acetylcholine Receptor, Spinal Cord, Limbic System
20 Apr 2017
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Document Summary
Most widely used group of pharmacological agents. Neurons: dendrites receive info, cell body integrates into to determine if ap will fire, communicate with each other via neurotransmitters. Projection neurons: axons project from one brain region to another. Neural circuits: integration of information from interneurons and projection neurons to form output, very complex. Drugs of abuse: used for behavioural effects created by imbalance in neurotransmission. *drugs that alter neurotransmitter concentration will act everywhere that transmitter is found. Nmda (our focus) and non-nmda receptors, all excitatory. Nmda = ion channels (na+ and ca2+ influx, k+ efflux) Gabaa = cl- channel (inhibitory), target for sedative hypnotics, decrease activity for calming effect. Projection neurons associated with learning, memory, and cognition (lost in. Limbic system: mood/behaviour (linked to drug-seeking behaviour and psychosis) 5 subtypes of receptors (d1-d5) linked to g proteins. D2 = inhibitory ( camp, presynaptic and postsynaptic) Cell bodies in midbrain and brainstem & project throughout brain.
