BIOM 4070 Study Guide - Quiz Guide: Hydroxylapatite, Macrophage, Growth Hormone
Document Summary
Blood vessels in perichondrium, oxygen and nutrients diffuse through gs. Replace ecm slowly, less efficient with age. Becomes less hydrated more rigid diffusion decreases. Ecm = basophilic (gag"s a(cid:374)d pg"s are net negative) Found in respiratory tract, fetal skeleton, bone articulations, epiphyseal plates. Territorial matrix: staining darker around cells (higher (cid:272)o(cid:374)(cid:272)e(cid:374)tratio(cid:374) of pg"s a(cid:374)d. Chondrocytes have lots of golgi, rer, and mitochondria. Similar to hyaline but with elastin meshwork too. Very flexible, springs back into place when deformed. Rer (cid:271)ut less golgi (cid:894)less gag"s a(cid:374)d pg"s(cid:895) Fibrous regions have fibroblasts, rich in collagen i. Interstitial growth: chondrocytes divide and make ecm, isogenic nests prominent (trapped in ecm) Appositional growth: chondroprogenitors in perichondrium, make cartilage on outside edge of existing cartilage, *only if perichondrium is present t m. Limited by avascularity and reduced mobility (trapped in ecm) Even then, progenitor cells usually form dense fibrous ct scar or calcified tissue rather than new cartilage.