BIOM 4070 Study Guide - Quiz Guide: Hydroxylapatite, Macrophage, Growth Hormone

176 views7 pages

Document Summary

Blood vessels in perichondrium, oxygen and nutrients diffuse through gs. Replace ecm slowly, less efficient with age. Becomes less hydrated more rigid diffusion decreases. Ecm = basophilic (gag"s a(cid:374)d pg"s are net negative) Found in respiratory tract, fetal skeleton, bone articulations, epiphyseal plates. Territorial matrix: staining darker around cells (higher (cid:272)o(cid:374)(cid:272)e(cid:374)tratio(cid:374) of pg"s a(cid:374)d. Chondrocytes have lots of golgi, rer, and mitochondria. Similar to hyaline but with elastin meshwork too. Very flexible, springs back into place when deformed. Rer (cid:271)ut less golgi (cid:894)less gag"s a(cid:374)d pg"s(cid:895) Fibrous regions have fibroblasts, rich in collagen i. Interstitial growth: chondrocytes divide and make ecm, isogenic nests prominent (trapped in ecm) Appositional growth: chondroprogenitors in perichondrium, make cartilage on outside edge of existing cartilage, *only if perichondrium is present t m. Limited by avascularity and reduced mobility (trapped in ecm) Even then, progenitor cells usually form dense fibrous ct scar or calcified tissue rather than new cartilage.