BIOM 4090 Study Guide - Final Guide: Vitamin B12, Vitamin K Deficiency, Chronic Kidney Disease
2 Dec 2017
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Synthesis: histamine; eicosanoids: major classes of pro-inflammatory mediators: S = 8-12 h i = 12-36 h l = 36-72 h. *prednisone (oral) has 4x the potency as cortisol. *dexamethasone is longer acting with 25x the potency as cortisol (inject once per day) Drugs used in hemorrhagic diseases: vitamin k: Vitamin k1: phytonadione (foods) *available for oral or parenteral use; intravenous route give slow; anaphylaxis. *vitamin k requires ~6 hrs for effects; very safe. *vitamin k used for anticoagulant activity; vitamin k deficiency; newborns prevent hemorrhagic disease: antifibrinolytic agents: Fibrinolytic inhibitors: aminocaproic acid: blood products (replacement factors): Desmopressin acetate *available as injectable or nasal spray (high dose) Protamine sulfate *give iv slowly to avoid collapse; high doses can produce anticoagulant effects. Oral therapy ferrous salts usually adequate (b/c this form is better absorbed) Intravenous therapy iron dextrans also used (complexed with sugar) *also available alone as injectables: growth factors:
