BIOM 3040 Study Guide - Final Guide: Tubulin, Colchicine, Bone Morphogenetic Protein 4
30 Jan 2018
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Induction: the chordamesoderm sends signals to the ectoderm instructing it to develop into neural tissue (neural plate) Neural tube formation: neurulation: the neural ectoderm folds to form a tube, running the length of the embryo. Regionalization and specification of the neural tube: brain develops rostrally while the spinal cord develops caudally. Proliferation and migration: neural crest cells migrate to form the pns while proliferation within the brain allows for growth. Connection and selection: axon outgrowth and synapse formation once cells are specified by type and in the right place. Induction of neural ectoderm by chordamesoderm: chordamesoderm lies below ectoderm prior to neurulation, the ectoderm becomes determined as the presumptive neural ectoderm by signals from the chordamesoderm. Inducing signals activate genes responsible for the differentiation. If either microtubule formation of f-actin formation is inhibited, bottle cells do not form properly and neurulation does not occur: cytochasalin d.
