FOOD 4090 Study Guide - Final Guide: Animal Testing, Cell Culture, Health Canada

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Published on 17 Apr 2013
School
University of Guelph
Department
Food Science
Course
FOOD 4090
Professor
(10) 8. Read the following abstract
PURPOSE: Our aim was to examine the association between black tea consumption and risk of total
stroke and stroke types.
METHODS: A total of 74,961 Swedish women and men who were free of cardiovascular disease and
cancer at baseline in 1997 were followed up through December 2008. Tea consumption was assessed
with a questionnaire at baseline. Stroke cases were ascertained from the Swedish Hospital Discharge
Registry.
RESULTS: During a mean follow-up of 10.2 years, we ascertained 4089 cases of first stroke, including
3159 cerebral infarctions, 435 intracerebral hemorrhages, 148 subarachnoid hemorrhages, and 347
unspecified strokes. After adjustment for other risk factors, high tea consumption was associated with a
significantly lower risk of total stroke; however, there was no dose-response relation (P for trend = .36).
Compared with no tea consumption, the multivariable relative risk for four or more cups per day
(median, 5) was 0.79 (95% confidence interval [CI], 0.62-0.998). The corresponding relative risks were
0.80 (95% CI, 0.61-1.04) for cerebral infarction and 0.68 (95% CI, 0.35-1.30) for hemorrhagic stroke.
CONCLUSIONS: These findings suggest that daily consumption of four or more cups of black tea is
inversely associated with risk of stroke.
a) What type of study was used in this investigation? (1 mark)
b) Identify 2 strengths and 2 weaknesses of this type of study design. (2 marks)
c) Briefly design an animal study to investigate a similar question. Make sure to state your study
question and to explain the rationale for your decisions. (7 marks)
a. prospective (or cohort) study
b. pros:
less recall bias compared to other types of observational studies
long period of time
reflects free-living situation
provides data in human model
able to generate hypotheses for intervention studies
cheaper than intervention studies
can study large population
can study multiple outcomes
can establish temporal relationships
cons:
difficult to remove confounding factors
can only conclude about associations, not cause-and-effect relationships
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Document Summary

Purpose: our aim was to examine the association between black tea consumption and risk of total stroke and stroke types. Methods: a total of 74,961 swedish women and men who were free of cardiovascular disease and cancer at baseline in 1997 were followed up through december 2008. Tea consumption was assessed with a questionnaire at baseline. Stroke cases were ascertained from the swedish hospital discharge. Results: during a mean follow-up of 10. 2 years, we ascertained 4089 cases of first stroke, including. 3159 cerebral infarctions, 435 intracerebral hemorrhages, 148 subarachnoid hemorrhages, and 347 unspecified strokes. After adjustment for other risk factors, high tea consumption was associated with a significantly lower risk of total stroke; however, there was no dose-response relation (p for trend = . 36). Compared with no tea consumption, the multivariable relative risk for four or more cups per day (median, 5) was 0. 79 (95% confidence interval [ci], 0. 62-0. 998).

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