MBG 4270 Study Guide - Midterm Guide: Writhe, Dna Gyrase, Top1

• School: University of Guelph
• Department: Molecular Biology and Genetics
• Course: MBG 4270
• Professor: Mark Baker

Document Summary

Mbg 4270 dna replication, recombination and repair. Passive all it does is store information : like any other data-storing device, it needs to be read, copied, and manipulated by other biomolecules. Dynamic: biomolecules interact with dna in different ways, bending, copying, denaturing, packing, walking-on it , breaking, repairing it, etc. Acidic material in chromosomes: nuclein : freidrich miescher, switzerland, 1869. Significance of nuclein as the genetic material not known. In 1928, frederick griffith demonstrated that stable inheritance of genetic traits in bacteria occurred via transformation : transforming principle was the responsible agent. 1944 avery, macleod and mccarty proved that the transforming principle was. 1952 alfred hershey and martha chase showed that dna carries genetic information in some bacterial viruses. 1953 double helical structure of dna determined by watson and crick (franklin and wilkins) Nucleic acid: macromolecule composed of phosphoric acid, pentose sugar and organic bases.