MCB 2050 Study Guide - Final Guide: Nucleoside, Copii, Pentagon

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Mcb study notes- for final eukaryotes have a membrane bound nucleus with a nuclear envelope, nuclear pores and an internal nuclear structure. Prokaryotes have a region where the chromosome is located (nucleoid) Characteristics irregular shape, one per cell largest organelle. Functions: compartmentalization of cellular activity and genome, coordination of cellular activities. Every process that occurs from the body comes from nucleus. Nuclear envelope- nuclear membrane, lamina and pores. Nuclear envelope: function separates nuclear content from cytoplasm- genome from cytosol, transcription from translation. Selective barrier (size specific)- establishes composition of nucleus. Thin meshwork of long filament like proteins. Mutations in lamin genes responsible for several human diseases (hutchinson-gilford progeria syndrome- premature aging in children due to point mutation in lamin a gene and destabilization of lamina) Inner and outer membranes of nuclear envelope fuse into pores. Complex supramolecular complex, fits into the pore, and reduces functional diameter. Highly conserved- integral and peripheral outer and inner membrane proteins.

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