MCB 3010 Study Guide - Midterm Guide: Guanine Nucleotide Exchange Factor, Persistence Length, Cytokine Receptor

• School: University of Guelph
• Department: Molecular and Cellular Biology
• Course: MCB 3010
• Professor: Scott Ryan

Document Summary

Feedback: ras is activated by guanine nucleotide exchange (gdp release and gtp binding), which is catalyzed by upstream ras guanine nucleotide exchange factors (ras- In contrast, ras gtpase-activating proteins (ras-gaps) increase the rate of gtp hydrolysis by ras and therefore inactivate it. Guanine nucleotide dissociation inhibitors (gdis) prevent the association of some gtpases with their gefs, thereby keeping the. Feedback: upon notch binding to delta, a plasma-membrane-bound protease cleaves off a cytoplasmic segment of notch, which enters the nucleus to activate the expression of target genes. The fragment acts by binding to a dna-binding protein and converting it from a transcriptional repressor into a transcriptional activator. Feedback: ph domain preferentially bind to pi(3,4,5)p3 (e) produced by pi 3-kinase. Feedback: both the cytokine receptor (left) and the tgf receptor (right) are enzyme- coupled receptors and are noncovalently associated with cytosolic tyrosine kinases and serine/threonine kinases, respectively. R-smads can form dimers or trimers with a co-smad.