MICR 3330 Midterm: Midterm Notes
10 Mar 2017
School
Department
Course
Professor
Document Summary
Topic 1: viruses in the news, most recent ebolavirus outbreak (december 2013- Index case (the first known person to have the virus) emile ouamouno in. Total to march 27th, 2016: cases: 28, 646, deaths: 11, 323. Case fatality rate: 11, 323/28, 646 = 43% Ebolavirus taxonomy (ictv) (from ebola river democratic republic of congo) Species: zaire ebolavirus, sudan ebolavirus, tai forest ebolavirus, bundibugya ebolavirus, reston ebolavirus (after reston va) Viruses: many isolates belonging to one of the 5 species. Genomes is ssrna negative sense (hence written 3" to 5" not translated) Negative genome is replicated to positive (mrna) sense, then translated. For positive (coding) sense starting at 5" end the following orfs for proteins. Np nucleoprotein, major protein coating rna genome. Vp35 viral protein, 35 kda size rna polymerase co-factor. Vp40 viral proteun, 40 kda size, matrix protein (b/w nucleocapsid and envelope) Sgp major secreted glycoprotein, may confound immune system. Vp30 viral protein 30 kda, transcription factor.
