MICR 4430 Study Guide - Midterm Guide: Hpv Vaccines, Measles Vaccine, Hepatitis B

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Chemical nature of the hpv virus structure genome: dsdna size: 9kb. Range of lesions caused by hpv (e. g. from benign warts to epithelial carcinomas) & types. E5: amplifies viral genome (upper layers (p53/rb) epithelium) How early and late gene expression is regulated during productive infection. Hpv genome nucleus 3 regions: long control region (lcr), early region (e), late region (l) Lcr: regulates viral replication + controls transcription of some early genes. E4: amplifies viral genome (upper layers of epithelium) L1 & l2: viral capsid, expressed late in infection (upper layers of epithelium) The role of cellular differentiation of the cutaneous epithelium in the hpv life cycle: basal layer has lots of stem cells divides, while dividing, virus genome partitioned. 3. into daughter cells one of daughter cells detaches from basal layer moves to stratum + differentiates. Infected cells that leave basal layer remain active in cell cycle because of.