MBG 3050 Midterm: Midterm Notes

• School: University of Guelph
• Department: Molecular Biology and Genetics
• Course: MBG 3050
• Professor: Nina Jones

Document Summary

During each meiosis at least once in each arm after pairing. Ensures constancy of chromosomes from one generation to the next. Errors disrupt integrity of genome and lead to formation of an individual or cell lineage with an abnormal number of chromosomes (from non-disjunctions i. e. abnormal chromosome segregation most frequent in meiosis 1 and in females) Meiosis 1: duplicated maternal and paternal homologs undergo synapsis, pair together to form bivalents, recombination occurs at chiasmata; physical break and rejoining, chromosomes separate. Meiosis 2: chromosomes separate again but there is no dna duplication. Metacentric: centromere is in the middle of the chromosome, equal distance from telomeres, equal distribution of dna (not genes) Submetacentric: centromere is halfway between middle and telomeres. Acrocentric: centromere is located at the end of the chromosome. Light areas are active material; dark bands are inactive. Standard chromosome fish: single type of purified dna fragment is labelled and denatured, homogenous dna probe, single probe bound.