MCB 4010- Midterm Exam Guide - Comprehensive Notes for the exam ( 43 pages long!)
11 Oct 2017
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Lecture 16 regulation of apoptotic cell death. Regulated cell death was being studied by developmental biologists and immunologists. Cell death is an active and regulated cellular process (possibly gene-directed: removal of transient embryonic structures during development, removal of cells that are no longer required or potentially harmful in the adult. Several groups demonstrated that inhibition of protein synthesis could prevent cell death in the metamorphosing tadpole tail, in metamorphosing insect muscle and in glucocorticoid-treated thymocytes. Apoptosis is the molecular and morphological process leading to controlled cellular self destruction. Described the phenomenon of physiological cell death. Named this process apoptosis (greek for falling off) Cell is dismantled and packaged into apoptotic bodies: cell shrinkage, detachment from neighboring cells, nuclear condensation and fragmentation. Lecture 16: plasma membrane blebbing, blebs pinch off to form apoptotic bodies, recognition and removal of apoptotic bodies by macrophages. Internucleosomal dna fragmentation is a biochemical feature of apoptotic cells.
