NUTR 4210 Final: Metabolically healthy obese

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Department
Nutrition
Course Code
NUTR 4210
Professor
Lindsay Robinson

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Obesity & metabolic phenotypes
Lean, healthy
Metabolically healthy obese (MHO)
Lean, metabolically obese
Metabolically unhealthy obese (MUHO)
Study: as BMI increases, risks of type 2 diabetes and cardiovascular disease increase, but
the increase is less steep for MHO than for the general population
Unhealthy obesity
Increased
Central obesity (visceral fat)
Hyperinsulinemia
Adipocyte stress
White adipose fibrosis
Inflammatory cytokines
Improperly stored fat (ectopic fat)
Decreased
Adiponectin
New healthy adipocytes
Glucose tolerance
Study: MHO were not at risk for CVD, lean and obese with more than 2 metabolic
abnormalities has elevated risk of death, MUHO also had elevated risk
*MHO maintained metabolic health throughout 7-year study
Study: MHO (<2 CVD risk factors) and MUHO (<2 CVD risk factors) had different body
composition (different amount of fat and where it is stored) and thus different
cardiometabolic profiles
Inflammasome: multiprotein complex that leads to more inflammatory mediators in
adipose when activated
Study: MHO and MUHO again defined by presence of CVD risk factors (already
undergoing surgery)
More NLRP3 (an inflammasome) more insulin resistance in MUHO
More expression and secretion of IL-1β in visceral adipose of MUHO
MUHO has a less favorable inflammatory profile than MHO!
Inflammasome may be a useful target in treatment/prevention of obesity
induced IR
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Description
Obesity & metabolic phenotypes  Lean, healthy  Metabolically healthy obese (MHO)  Lean, metabolically obese  Metabolically unhealthy obese (MUHO) Study: as BMI increases, risks of type 2 diabetes and cardiovascular disease increase, but the increase is less steep for MHO than for the general population Unhealthy obesity Increased  Central obesity (visceral fat)  Hyperinsulinemia  Adipocyte stress  White adipose fibrosis  Inflammatory cytokines  Improperly stored fat (ectopic fat) Decreased  Adiponectin  New healthy adipocytes  Glucose tolerance Study: MHO were not at risk for CVD, lean and obese with more than 2 metabolic abnormalities has elevated risk of death, MUHO also had elevated risk *MHO maintained metabolic health throughout 7-year study Study: MHO (<2 CVD risk factors) and MUHO (<2 CVD risk factors) had different body composition (different amount of fat and where it is stored) and thus different cardiometabolic profiles Inflammasome: multiprotein complex that leads to more
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