NUTR 4210 Study Guide - Final Guide: Megestrol Acetate, Chemotherapy, Strength Training
8 Dec 2017
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Progression: initiation: dna damage, irreversible changes to cell i. e. ros, environmental factors, promotion: evade immune system, promotion of cell survival, angiogenesis. Obesity is associated w/ increased risks of many cancers, namely colorectal cancer. & breast cancer (post-menopausal) most well studied, established links w/ obesity: for every 2kg/m2 increase in bmi > colorectal cancer increases by 7, 2 cm increase in waist circumference > colorectal cancer increases by 4% Obesity = favourable environment for tumour development: associated with metabolic abnormalities that may increase cancer risk! Thursday, december 7, 2017: altered hormone metabolism, increased igf-1, sex hormones i. e. increased circulating estrogen. Insulin and igf-1 receptors are over-expressed in many types of cancer! i. e. adipose tissue increases secretion of estrogen in post-menopausal women. Both hormones increase cell growth/proliferation, decrease apoptosis, & promote angiogenesis: abnormal adipokine production! Increases nfkb and stat3 activation: increases in ammatory cytokines tnfa and il-6 > chronic in ammatory state, promotes cell proliferation and cell survival.
