PATH 3610 Study Guide - Final Guide: Portal Hypertension, Portal Vein, Coagulation

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Rob Foster

Document Summary

~ made of multiple lobes, very fragile, held up under the diaphragm. ~ vein brings blood from intestine (portal vein > between 2 capillary beds) ~ blood flows down past hepatocytes and goes to central vein which goes back through vena cava to heart&body. Max daily dose = 4g (= 8 extra strength = 500mg) Toxic dose with alcohol = 2. 5g (5 x 500mg, 3-4 drinks) Causes the production of free radicals in the liver damages liver cells (stimulates regulated cell death) 56 000 per year in usa with acetaminophen toxicity. Hepatocytes are arranged in close proximity to blood vessels and bile ducts. Liver has tremendous blood supply; supplied from hepatic arterioles and the portal vein. Bile passages collect bile from individual hepatocytes and transport it to the bile duct then gallbladder. ~ the liver is a gland, hepatocyte is a gland. Hepatocytes (epithelial) -stable cell type (low mitotic activity) Endothelial cells ~ easy to set thrombosis.