PSYC 3030 Study Guide - Midterm Guide: Resting Potential, Phenelzine, Yohimbine
28 Sep 2016
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Psyc*3030 - neurochemical basis of behaviour - exam #1. Ache is found: pre-synaptically, in the cholinergic neuron. 2: at neurotransmitter junctions, released by muscle cells very precise regulation of nmj function; ache metabolizes ach very quickly to allow muscle to relax until next stimulation. Drugs that affect ach synthesis, storage, and release. Blockade of ach synthesis: some drugs can inhibit chat activity, but they are not selective, some drugs can inhibit the high-af nity choline transporter, blocked by hemicholinuim-3 (hc-3) - does not cross the bbb. Blockade of ach storage: vesamicol inhibits the vesicular ach transporter. Blockade of ach release: botulinum toxin -> found in canned foods, 1g can kill 350,00 people by paralysis and asphyxiation. Cholinergic synapse: botox prevents ach release at muscular junction, the fusion of ach with ?, blocks release. Docking: snare proteins: paralysis due to no signal to stimulate the muscle, some wrinkles are due to overactive muscles, botox can treat this.
