PSYC 3030 Study Guide - Final Guide: Pentobarbital, Vigabatrin, Selective Serotonin Reuptake Inhibitor

• School: University of Guelph
• Department: Psychology
• Course: PSYC 3030
• Professor: Boyer Winters

Document Summary

Inhibitory amino acid, used only as a neurotransmitter. Gaba (gamma-aminobutyric acid) and glycine (mainly in spinal cord) Antagonism leads to convulsions (contraction/relaxation of muscles), death. From glutamate by glutamate de-carboxylase (gad), selective marker for gabaergic neurons. Gaba is broken down by gaba aminotransferase (gaba t), makes glutamate as a by-product. Gaba neurons contain glutaminase (glutamine into glutamate) and gad (glutamate into. Mostly uptaken by astrocytes (gat3), also contain gaba t. Final product of inactivation is succinate and glutamate. 10-40% of nerve terminals in the cortex, hippocampus, and substancia nigra. Cerebellum, striatum, globus pallidus, olfactory bulbs, spinal cord. Similar to a, but more sensitive to gaba. Do not respond to typical allosteric modulators of gaba a (bdzs, barbs) Alpha (6 isoforms), beta (4 isoforms), gamma (3 isoforms), delta. Picrotoxin and metrazol: non-competitive, seizures: orthosteric gaba binding site. Agonized by muscimol, competitive agonist, hallucinations by inhibiting 5-ht release. Sedative hypnotics: relaxing/sleep producing, anxiolytics, anticonvulsants; impair attention and memory.