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Study Guide

ACB 330- Midterm Exam Guide - Comprehensive Notes for the exam ( 37 pages long!)

37 Pages
21 Views
Spring 2018

Department
Anatomy and Cell Biology
Course Code
ACB 330
Professor
Kulyk William
Study Guide
Midterm

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U of S
ACB 330
Midterm EXAM
STUDY GUIDE
Genomic equivalnace: lecture 1
Roux study:1.2 of genetic info was in each side of blastomere. Each
blastomere is TOTIPOTENT: contains all info required to form entire
embryo.
Spemann:each nucleus retains all genetic info until ~16 cell stage
Somatic cells remain totipotent at later stages, however they decline as
age of nuclei increases.
Blau: differentiated live cells retain genes for muscle protein, that it
no longer needs.
Somatic cells retain ALL genes through development
Differentiation comes from gene expression not loss
find more resources at oneclass.com
find more resources at oneclass.com
Regulation of Gene Expression: Lecture 2
5’3’
Promoter region: RNA polymerase II binds to nuclease here. moves dwn
DNA 5’3’. Makig priar RNA trasript. @ trasriptio teriatio
site. RNA pol II leaves.
Pre-MRNA: contains all exons, leader sequences and introns. It has a
7’ethl ap: ritial or MRNA to id to riosoes
Poly A tail: resist to endonuclease attack. To add this tail, cleave off end, use
ATP and Poly(a) polymerase.
MRNA: has only exons + 7 cap +poly A tail.
Exon splicing: SnRNPs form spliceosome which remove intron
Regulation:
1) Transcriptionally: gene can be transcribed to be active/inactive
2) RNA processing.: exon splicing. Different combinations of exons.
Cause huge difference: bcl-x either inhibits or promotes apoptosis
bases on the exons.
3) RNA stability: longevity of transcripts can vary. Stable=transcribed
more readily. Uses microRNAs, to tag
4) Translation: mRNA may be prevented from matching up with a
ribosome
5) Post-translational modifications:
Proteolytic cleavage: yields different proteins from single polypetide.
find more resources at oneclass.com
find more resources at oneclass.com

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Description
[ACB 330] Comprehensive spring guide including any lecture notes, textbook notes and exam guides.find more resources at oneclass.com Genomic equivalnace: lecture 1 Roux study:1.2 of genetic info was in each side of blastomere. Each blastomere is TOTIPOTENT: contains all info required to form entire embryo. Spemann:each nucleus retains all genetic info until ~16 cell stage Somatic cells remain totipotent at later stages, however they decline as age of nuclei increases. Blau: differentiated live cells retain genes for muscle protein, that it no longer needs. Somatic cells retain ALL genes through development Differentiation comes from gene expression not loss find more resources at oneclass.com
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