ACB 330- Final Exam Guide - Comprehensive Notes for the exam ( 37 pages long!)
29 Mar 2018
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Roux study: 1. 2 of genetic info was in each side of blastomere. Each blastomere is totipotent: contains all info required to form entire embryo. Spemann: each nucleus retains all genetic info until ~16 cell stage. Somatic cells remain totipotent at later stages, however they decline as age of nuclei increases. Blau: differentiated live cells retain genes for muscle protein, that it no longer needs. Somatic cells retain all genes through development. Differentiation comes from gene expression not loss. Promoter region: rna polymerase ii binds to nuclease here. Pre-mrna: contains all exons, leader sequences and introns. 7"(cid:373)ethl(cid:455) (cid:272)ap: (cid:272)riti(cid:272)al or mrna to (cid:271)i(cid:374)d to ri(cid:271)oso(cid:373)es. To add this tail, cleave off end, use. Mrna: has only exons + 7 cap +poly a tail. Exon splicing: snrnps form spliceosome which remove intron. Regulation: transcriptionally: gene can be transcribed to be active/inactive, rna processing.
