BMSC 230 Study Guide - Final Guide: Phosphatidylcholine, Lipid Droplet, Phosphatidylserine

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Anchors the growing fa chain to fas (fatty acid synthase) Carries the rxn intermediates from 1 enzyme active site to the next. First, we need to load" fas with substrates acetyl coa and malonyl coa: acetyl coa -----at----> -ketoacyl acp synthase cys s acetyl, malonyl coa -----mt-----> malonyl-acp (priming reaction) Intermediates of fa synthesis remain attached to fas via 2 thiol groups: Transfers 2c"s (from acetyl coa) to malonyl coa acp. *the co2 released is from the hco3- in the very first step. Double bond b/w c2 and c3 is reduced. Transfer of butyryl group from acp to ks. Priming rxn takes place: malonyl coa malonyl-acp. Condensation (ks): butyryl group is condensed to malonyl. Free palmitate is released from acp of fas by hydrolysis. If there"s a lot of glucose, there"ll be a lot of atp as well. Atp inhibits isocitrate dehydrogenase, inhibiting the tca cycle. This accumulation will reverse the reaction so that citrate is formed from isocitrate.

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