PHPY 304 Study Guide - Midterm Guide: Lipophilicity, Signal Transduction, Bioavailability
23 Nov 2016
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Steve hall tue oct 18 11:57:44 pdt 2016. Pharmacokinetics (4 processes) absorption, distribution, metabolism, excretion; what the body does to the drug. Pharmacodynamics drug-receptor interactions and signal transduction; what the drug does to the body pka of drug. De ned as the ph at which half of the drug is ionized. Most drugs are either weak acids or bases. Better absorbed when the drug is not ionized. The fraction of a po drug that reaches circulation. Ba = (auc oral / auc iv) * 100. Vol of blood from which a drug is irreversibly removed per unit of time (ml/min/kg) Sum of clearance of that drug by all organs. Theoretical or apparent volume in which total amt of administered drug should be uniformly distributed to acct for plasma or blood conc. High vd = evenly dist out of uids and conc in fat. Clearance of lipophilic drugs longer time to be excreted. slower clearance, longer half-life.
