[PHPY 304] - Final Exam Guide - Comprehensive Notes for the exam (63 pages long!)

• School: U of S
• Department: Physiology and Pharmacology
• Course: PHPY 304
• Professor: Desai Kash

Document Summary

Skeletal muscle nm type nicotinic receptors rapidly reversible stimulation with ach released from motor nerves physiological skeletal muscle contraction (in myasthenia gravis autoantibodies destroy these receptors skeletal muscle weakness. Drug therapy in specific patient groups: list principles of drug therapy in pregnant patients. Principles of drug administration during pregnancy: the first trimester is the most important, when the fetal development is most sensitive to drugs. Towards the 3rd trimester, greater risk can be taken starting drug therapy. Factors that affect drug transfer across the placenta: molecular weight of the drug: drugs with a mol. > 500d have an incomplete transfer across the placenta. < 500d, therefore most drugs cross over to the fetal circulation. pka of the drug and degree of ionization: ionized drugs transfer incompletely across the placenta, however this may not always be true. Role: protects the fetus by efflux of drug from the fetal to maternal circulation. Drug efflux transporters are expressed in the placental barrier.