BIOL130 Study Guide - Final Guide: Integral Membrane Protein, Karyotype, Microvillus

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A (cid:374)et(cid:449)ork of fi(cid:271)res for(cid:373)i(cid:374)g (cid:858)s(cid:272)affoldi(cid:374)g(cid:859) (cid:449)ithi(cid:374) (cid:272)ytoplas(cid:373) Unlike our skeletons: cytoskeleton is dynamic-> constantly being reorganized. Ser(cid:448)es as (cid:271)oth (cid:858)(cid:271)o(cid:374)es(cid:859) a(cid:374)d (cid:858)(cid:373)us(cid:272)les(cid:859) of the (cid:272)ell. Once thought to be feature of eukaryotes only. Recent advances in microscopy have shown that analogs of all the major cytoskeletal elements exist in prokaryotes. Form a network through cytoplasm of most animal cells, extending out to cell periphery. Often anchored on plasma membrane at cell-cell junctions called desmosomes. Strands consist of long fibrous proteins, each with globular n-terminal head, globular c- terminal tail and -helical rod domain. Central rod domains are all similar in size and aa sequence, so form ropes of similar diameter. Globular ends are quite variable, interacting with different components within cell. Intermediate filaments even in different cells within the same organism can be composed of different proteins. Keratins are the most diverse class of intermediate filaments.

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