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BIOL130 Study Guide - Midterm Guide: Cell Membrane, Signal Recognition Particle, G Protein–Coupled Receptor

Course Code
Niels C Bols
Study Guide

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Monday, November 23, 2015
Bio130 top 10 Take-up Midterm 2
Membrane carrier proteins are distinguished from ion channels by the
following feature:
oMembrane carrier proteins can become saturated if the
concentration of their cargo mol’c is high whereas channels allow
passage of ions at very high rates as long as there is a diffusion
To be inserted into a membrane, a protein must have…
oA signal sequence on its N terminus that would be recognized by a
signal recognition particle (SRP) in the cytoplasm
oAt least two sequences of hydrophobic AAs (the second one will be
the stop sequence and will be forever in the membrane…single
What’s the difference between constitutive and regulated secretion?
oIn regulated secretion, the secreted substance is very high
concentrations in vesicles on the sytosolic side of the plasma
oRegulated secretion occurs only in specialized cells, constitutie
occurs in all cells
oConstitutive occurs constantly, while regulated occurs in response
to an outside signal
Journey of a lysosomal acid hydrolase:
1. Recognition by SRP in cytosol
2. Translation into ER lumen
3. Removal of signal sequence by peptidase
4. Vesicular transport to cis face of Golgi
5. Budding off trans face of Golgi
6. Fusion with endosome
Receptors for hydrophilic (AKA AAs, peptides) and lipid-soluble hormones
(AKA steroids…which is the one that is a transcription factor) are similar in
which of the following ways?
oBoth receptor types change shape upon hormone binding
Which of the following statements about mol’cr switches is false?
oPhosphates remove the phosphate from GTP on GTP-binding
proteins, turning them off
(Study molecular switches and compare/contrast features)
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