BIOL308 Study Guide - Lysine, Acylation, Ribonuclease P
8 Dec 2013
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Document Summary
List and briefly explain different mechanisms of post-transcriptional control of gene. Localization of mrna positioning of mrna close to the sites where the protein produced from mrna is required. Efficient way to unevenly distribute proteins in polarized cell. E. g. , maternally inherited mrnas such as bicoid are asymmetrically distributed in embryo. Rna editing rna alteration in mrna sequences. E. g. , in mitochondria of protozoa, and mitochondria and chloroplasts in plants, there is addition or deletion of u residues. Translational control switch coordinate and opposite translational regulation of ferretin and transferrin receptor. mrnas for both proteins have ire which binds iron-responsive binding protein irp which is sensitive to iron concentration. There is some kind of mechanism that normally prevents pre-mrna from exiting the nucleus before it is spliced. This was illustrated in an experiment where hsp30 mrna was not observed unless cells were treated with cyclohexamide. Trans-splicing is the creation of multiple monocistronic mrna from a single polycistronic pre- mrna.
