BIOL355 Study Guide - Final Guide: Proteoglycan, Granulation Tissue, Itch

• School: University of Waterloo
• Department: Biology
• Course: BIOL355
• Professor: Cheryl Duxbury

Document Summary

Loss of telomeres from actively dividing cells is typically 50-150 bp/cell doubling in vitro and 15-50 bp/cell in vivo: what"s the proble(cid:373) with staggered e(cid:374)ds, cell will think it"s broken or frayed b/c of the overhang. In contrast, telomerase activity was not detected in 22 out of 22 normal somatic cell line cultures and in 50 out of 50 normal or benign biopsies of 18 different tissues. Increase the maximum life span for tissue cultured cells (past the ha(cid:455)fli(cid:272)k"s limit of 50: when they re-lengthening the telomeres in the cells that are already in. Phase 3 (cells scenescing or dying) : they were able to change the morphology to move back towards. Phase 2 cells i. e. reversing of aging process! Telo(cid:373)eres, hayfli(cid:272)k"s li(cid:373)it a(cid:374)d the cell cy(cid:272)le: comparison of cell line telomere length, germ line: telomere length remains constant with age, somatic cell line: telomere length decreases with age, premature aging: telomere length decreases very quickly with age.