BIOL444 Study Guide - Final Guide: Necrotizing Fasciitis, Bartonella Henselae, Cat-Scratch Disease
19 Dec 2016
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Microbial surface components recognizing adhesive matrix molecules: protein a, capsule, fibronectin-binding protein, collagen-binding protein, clumping factor, coagulase. Protein a = neutralizes antibodies by binding to the fc portion instead of the antigen binding site. Panton-valentine leukocidin: pore-forming toxin that kills phagocytes and epithelial cells. Alpha-toxin hemolysin: pore-forming toxin that kills many types of cells. Exfoliative toxin: disrupts intercellular junctions of epithelia. Abscesses, cellulitis, impetigo, scalded-skin syndrome, necrotizing fasciitis. Antibiotic therapy and identify carriers: streptococcus pyogenes. Microbial surface components recognizing adhesive matrix molecules: m protein, fibronectin-binding protein, epa. Disguising as self: m protein, hyaluronic acid capsule. C5a peptidase: reduce migration of neutrophils to the infected site. Streptococcal inhibitor of complement: disrupt mac formation. Streptolysin s: cell-bound hemolysin that kills when ingested. Lipoteichoic acid: cell wall component that can cause septic shock. Necrotizing fasciitis, strep throat, tonsillitis, scarlet fever, impetigo: clostridium perfringes. Alpha-toxin hemolysin: pore-forming lysis that kills many cells. Theta-toxin hemolysin: alters capillary permeability which is dangerous for the heart.
