CHEM333 Study Guide - Final Guide: Lactate Dehydrogenase, Pyruvate Dehydrogenase, Acetyl-Coa
19 Dec 2015
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Mark= 77. 8: the path that will allow the carbons contained in pyruvate to enter mitochondria and undergo utilization in the tca cycle is via lactate. Pyruvate is reduced to lactate by lactate dehydrogenase. Lactate can enter the outer membrane of mitochondria by mct1, mitochondrial monocarboxylate transporters. Lactate dehydrogenase can catalyze the conversion of lactate to pyruvate. Pyruvate can be oxidized to acetyl coa by pyruvate dehydrogenase. The blood can be detected for the levels of lactate. If lactate is constant or decreases in the blood as the work out intensifies, this would mean it is being used as an energy source: nadh cannot pass inner mitochondrial membrane. Hydrogen is taken to mitochondria by other carriers. The malate-aspartate shuttle combines 4 substrates and two protein transporters. The hydrogens accumulated in the hms might enter mitochondria through this shuttle. The hydrogens from nadph can be transferred onto nadh by transhydrogenase. Mitochondrial lactate oxidation complex and an adaptive role for lactate production.
