CHEM430 Study Guide - Final Guide: Hmg-Coa Reductase, Thyroid Peroxidase, Guanylate Kinase
29 Mar 2016
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Chapter 7 horomones types of horomone receptors: gpcrs. On cytoplasmic membrane, ligands on extracellular side, transmit signal to the cell interior through conformational change. Receptors function protein kinases phosphorylate substrate proteins which noncovalently bind and activate downstream regulatory proteins (unlike. Gpcrs that send signals through noncovalent interactions with downstream adapters) Nuclear hormone receptors: activated by thyroid hormones, alpha or beta, recognize dna sequences, usualy aggtca, diferent dimers recognize in diferent orientations, same type of receptor used for enzyme induction by xenobiotics. Endocrine glands under control by hypophyseal gland or pituitary: both controlld by hypothalamus, hyposeal gland extends downwards from it. Hyposeal gland has anterior and posterior lobes. Posterior contains nerve endings of hypothalamic nerves. Anterior controlled by hypothalamic peptide horomones then release peptide horomones that stimulate peripheral glands. Adrenal gland stimulated by acth, which is stimulated by crh. Cortisol has negative feedback on both: same regulation as cortisol.
