HLTH 210 Midterm: 3- Post-Natal Development Summary

• School: University of Waterloo
• Department: Health Studies
• Course: HLTH 210
• Professor: David- Antoine Williams

Document Summary

Interstitial: hyperplasia and accretionary growth throughout thickness of tissue. Bone formation: bone is a replacement tissue, deposition of mineral matrix onto cartilage template, by birth most cartilage is replaced with bone but some remains in adult skeleton. Endrochrondal ossification: bone develops by replacing hyaline cartilage, bones at base of skull and long bones, starts with formation of cartilage, btw. 6-8 weeks of fetal development some mesenchymal cells differentiate into chondroblasts secrete factors to form cartilaginous matrix: hyaluronic acid, chondroitin sulfate, collagen fibers, and water now called chondrocytes: interstitial and appositional growth, perichondrium membrane covers cartilage. Endochondral ossification follows five steps. (a) mesenchymal cells differentiate into chondrocytes. (b) the cartilage model of the future bony skeleton and the perichondrium form. (c) capillaries penetrate cartilage. Primary ossification center develops. (d) cartilage and chondrocytes continue to grow at ends of the bone. (e) secondary ossification centers develop. (f) cartilage remains at epiphyseal (growth) plate and at joint surface as articular cartilage.