KIN146 Study Guide - Final Guide: Folate Deficiency, Macrocytic Anemia, Pernicious Anemia
31 Aug 2018
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James lind british physician, lack of vit c in british sailors (chronic vit c deficiency scurvy) Vit c is necessary for collagen synthesis; we are in constant state of muscle turnover. Signs: fatigue, bone softening, anemia, hemorrhaging, teeth loosening. Casmir funk polish biochemist, isolated amine in rice w/ improved health of thiamin-deprives chicken. Vitamin = organic molecules, fit under micronutrient (needed in milli and micrograms), no energy contribution. Exist in individual units, not chains like macronutrients. Component of thiamin pyrophosphate (tpp); coenzyme for glycolysis & ecaa metabolism, work w/ pyruvate dehydrogenase (pdh: without pdh, we"re stuck in glycolysis (limited atp production) Deficiency: berberi lower limb paralysis, chronic weakness, weight loss. When outer shells of grains are removed greater risk of deficiency. Fad = electron acceptor transporter; involved in fat & cho metabolism. Importance: metabolism of other vitamins (folate, b6, k, niacin)
