Study Guides (248,000)
Canada (121,218)
Kinesiology (151)
KIN 217 (10)
n/a (3)

Oct_26.doc

3 Pages
125 Views
Unlock Document

Department
Kinesiology
Course
KIN 217
Professor
n/a
Semester
Summer

Description
Kin 217 – October 26 th Go HANNAH Paradox of Names -Why do Low Density Lipoproteins have higher density of TAG and Cholesterol than High density lipoproteins? - What happens when you centrifuge LDL and HDL -Apolipoproteins Apo-A -approximately 50-60% OF hdl MW Apo-B -20-25% of LDL mw Electrophoresis - decrease in diameter…HDL moves faster than LDL - The major apoproteins in HDL are Apo A, C, E - The only apoprotein in LDL is Apo-B00 - The mw of Apo-B is greater than Apo-A I or II - BUT Apo-B takes up only about 20% of LDL, while Apo-A takes up about 50% of HDL - The def of HDL and LD arise from the centrifugation results floating = LDL (between 1.996 to 1.063 g/ml) and sedimenting - Release of free fatty acids? o Hormone-sensitive lipase  Adipose cells have  Activated by glucagons  Inhibited by insulin o Free fatty acids in blood  Normally low levels  Serum albumin will bind most • Small pool exists - Diagnostic use of lipid and lipoprotein values o Most doctors don’t measure LDL cholesterol o Take total cholesterol measurement and use spectrometer..  They’ll measure HDL cholesterol  And then measure triacylglycerol (the backbone – glycerol) o Friedwald formula for the calculation of LDL concentration in plasma  LDL (mg/dL) – US – HDL – Triglyceride/5  LDL (mmol/L) – What we use (much smaller values) - HDL – Triglyceride/2.2 o Need to think about whether a test is feasible (if too expensive, not feasible) - Structure of glycogen o Series of figures from text o Long strings are 1 - 4 alpha chains… - How is energy injected into this process? o Glucose enters the cell  Phosphorylated to glucose-6-phosphate  Hexokinase in most tisues  Glucokinase in liver  Strong negative ∆ G - Glucose in the cell o G-6-P  Trapped in cell  (WHY? big negative charge on molecule…because of the phosphate!) - Fig 10.1 o What do we know about pyrophosphate? (When you see a rxn with pyrophosphate?)  It’s a high energy bond (resonance stabilization…huge negative G) …this will drive the formation of the UDP-glucose (basically setting
More Less

Related notes for KIN 217

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit