NE 481- Midterm Exam Guide - Comprehensive Notes for the exam ( 58 pages long!)

• School: University of Waterloo
• Department: Nanotechnology Engineering
• Course: NE481
• Professor: Frank Gu

Document Summary

Half life time taken for cp to fall to half elimination usually an exponential process. Bioavailability (f) fraction of dose that reaches systemic circulation depends on : first-pass clearance fh (fraction of dose escapes first passage through liver into circulation) absolute bioavailability. Metabolize protein, fat, carbohydrate store iron and vitamins produce plasma proteins. Fu = unbound fraction depends how tightly the drug is bound to proteins and cells in the blood. Clint = intrinsic clearance ability of liver to remove drug in absence of restriction imposed by blood flow and protein binding. Measures how active the metabolizing enzymes are with the particular drug as substrate. Vmax = max rate of conversion reaction at saturated substrate concentration. Km = michaelis constant describing binding affinity. Clint much less than qh (qh >> fu*clint) changing blood flow rate makes little difference to actual clearance rate (cid:1838)(cid:3009)=(cid:1858)(cid:1873) (cid:1838)(cid:3041) (cid:1838)(cid:3009)=(cid:1843)(cid:3009) i. e. capacity limited, low eh (cid:1838)(cid:3009)=(cid:1843)(cid:3009) i. e. capacity limited, low eh e. g. diazepam.