BIOL 331 Midterm: Response to After Midterm Material "Yellow Pages" Study Questions Organized, detailed responses to the "yellow page" questions found at the end of each lecture note. Restructured from the lecture notes so that it's easy to read and understand! Last 2 page
Document Summary
What we see as the familiar lysosome is one particular stage in cycle of late endosome/lysosome fusion. Macromolecules bind to complementary transmembrane receptor proteins, which accumulate in coated pits and are taken into the cell through endocytosis of clathrin coated vesicles receptor functions to concentrate ligand ligand is just thing that binds to receptor. Can you explain the intake of cholesterol into cells by receptor mediated endocytosis? cholesterol is found in circulating blood as cholesteryl ester in lipoprotein particles (low density lipoproteins or. Ldl is passed to late endosome and lysosome where cholesteryl esters are hydrolyzed to free cholesterol for new membrane synthesis. Increasing cholesterol concentration in cell will shut off synthesis of new ldl receptors and cholesterol synthesis (feedback control mechanism) Can you explain why 1/500 people develop heart disease in the age range of 35-45? relatively common mutation of ldl receptor exists in humans (1/500 are heterozygous for mutant allele)
