MICB 202 – 2011W
Immunology Review Questions - Topics 1 and 2.
1. What are the functions of Pattern Recognition Receptors (PRRs)?
2. Person A was born with a genetic defect that results in an inability to produce
complement component C3. Person B was born with a different genetic defect and is
unable to produce complement component C5. Who would have a more difficulty in
eliminating a bacterial infection? Why?
3. You surgically remove the thymus from both a newborn mouse and an adult mouse.
What effects would this have on the newborn mouse, and what effects would this have
on the adult mouse? Explain the differences or similarities.
Immunology Review Questions - Topic 3.
4. What are three major differences between class I MHC molecules and class II MHC
5. Why is it important that T cells undergo positive and negative selection during their
development? What type of selection do B cells undergo during their development?
What are the roles of positive and/or negative selection in each maturation pathway?
6. For a T cell to be activated, two “signals” are required. What is signal #1? What is signal
#2? Why is it important to require two signals to activate the T cell? What happens if
the T cell only receives one signal?
7. The innate and adaptive immune systems work together to maximize the protection
against infection by pathogens. What are some of the interactions between the
proteins/cells of the innate and adaptive immune systems?
Immunology Review Questions - Topic 4.
8. How does the human body defend itself against extracellular bacterial infections? Describe
more than one defense mechanism. Indicate whether each mechanism is part of the innate
immune responses or the adaptive immune responses.
9. Why is cell-mediated immunity required in the case of intracellular bacterial infections?
What cell types are involved in this response? Why is humoral immunity insufficient in
eliminating the infection?
10. Are cell-mediated immune responses the only type of immune responses occurring duringa
viral infection? If not, what other immune responses would be occurring, and what would
be their function?
11. When it is more appropriate to develop a humoral or antibody-mediated response?
When it is more appropriate to develop a cell-mediated response? 2
12. What type of response(s) do you develop when you are immunized with inactivated
poliovirus vaccine? Explain. In this vaccine, the virus particles are treated with
formaldehyde, and the viruses are not capable of infecting cells.
Immunology Review Questions - Topic 5.
13. Provide a definition of hypersensitivity and what are two subclasses that exist in the
human body? How are they alike? How are they different? (think about effector
mechanisms, cell types, speed of action etc)
14. Explain the proposed mechanism behind allergy shots. How are they thought to reduce
the severity of allergic symptoms?
15. Explain the basis for MHC based graft rejection? Identify the specific selection process
and what it does as well as where it occurs and when.
Immunology Review Questions - Topic 6.
16. In a particular immunodeficiency disease, patients’ B-cells are unable to express MHC
class II. MHC expression in all other cells is normal. In terms of the immune-system
cells and their activation