- Anaerobic: thrive without O2
Why is it important to identify the type bacteria?
Abx are different for each one.
What are anti-infectives drugs classfied by?
1. Susceptible organisms
2. Chemical structures
3. Mechanism of Action
What do anti-infectives do?
Effectively get rid of pathogen
What does antibiotic mean?
Natural substance produced by microorganism that
kills other microorganisms.
What are the two means of grouping widely used?
Chemical classes: usually are structurally similar and
usually share similar antibacterial properties and
Pharmacological classes: predict similar actions and
Review page 515 table 43.2.
What are the chemical classes and their mechanism of
MoA: Inhibition of cell wall synthesis
Chemical Classes: Penicillins, Cephalosporins,
MoA: inhibition of protein synthesis
Chemical Classes: Aminoglycosides, Tetracyclines,
MoA: disruption of plasma memberane
Chemical Classes: Azoles, Polyenes
MoA: inhibition of nucleic acid synthesis
Chemical Classes: Fluroquinolones
MoA: inhibition of metabolic pathways
Chemical Classes: Sulfonamides
What are three ways bacterias are eliminated through
Bacteriocidal: killing bacteria
Bacteriostatic: slow-growth process
Selective Toxicity: target unique differences btw
human and bacterial, fungal, and protozoan cells.
Explain each mechanism of action for anti-infectives:
1. Inhibition of cell wall synthesis
- Bacteria have a thick cell wall that causes high
- Bacteria also have “peptidoglycan”; strong,
repeating network of carbohydrate and protein
- Different drugs act on the cell wall difference
and use it to destroy the bacteria
2. Inhibition of protein synthesis
- Aminoglycosides change the shape of
ribosomal units necessary for protein synthesis