PCTH 325 Study Guide - Final Guide: Cardiac Output, Atropine, Curare
11 Apr 2017
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Clonidine a2 agonist decreases bp. Diphenydramine when taken for seasonal allergies causes drowsiness, when taken for sleep aid therapeutic effect. Finasteride blocks 5a reductase conversion of t to dht hair-growth side effect. Clopidogrel prodrug acts on cyp2c19 enzyme (may be affected by genes) Herceptin (trastuzumab) anticancer drug binds to specific protein; if lacking this protein won"t work genetic test to determine. Tylenol (acetaminophen) can cause acute liver injury in people with mutation in gene cd44. Coumadin (warfarin) blood thinner: people with mutations in cyp2c9 and vkorc1 gene metabolize it poorly. Drugs for biomarkers affecting drug safety (green depicts biomarker) Xalkori (crizotinib) inhibits defective gene product of alk and can shrink/stabolize tumors: anaplastic lymphoma kinase (alk) mutated protein that drives cancer growth (non-small cell lung cancer, protein is 2 genes fused together. Double mastectomy for brca1 mutation leads to defective apoptosis leaves cell proliferation unchecked: mutation cause 60% breast cancer and 40% ovarian cancer.
