PHAR 330 Study Guide - Midterm Guide: Vitamin K Epoxide Reductase, Cyp2C9, Warfarin
28 Mar 2016
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Pharmacogeneics: understand the role and structure of. 5q4 5 represents the chromosome number, q means the long arm, 4 means the posiion of that speciic gene on the chromosome you count from the centromere. Mulifactorial diseases (involve muliple genes and the environment) They either give rise to a condiion or they don"t. Most traits are polygenic (i. e. 1 trait coded by a number of altered and unaltered genes working together) Alzeimer"s, diabetes, cancer, eczema, schizophrenia: understand the diferences between the inheritance paterns associated with single gene disorders. Autosomal dominant: heterozygotes with one copy of the altered gene and they are afected. Autosomal recessive: homozygous and must have two copies of the altered gene to be afected. Sickle cell disease, cysic ibrosis, congeinal deafness, pku - X-linked recessive: males with an altered gene on the x-chromosome are always afected: understand that the environment can impact on some common complex condiions, appreciate the scope and impact of molecular biology.
