BIO 3170 Midterm: BIO3170 Midterm: BIO3170 Midterm 1: Lecture 1 - 6 Learning Objectives
11 Apr 2018
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Lectures 1 - 6 learning objectives: dna structure and the central dogma. Identify covalent bonds and non-covalent interactions important for the structure formation of the dna double helix. Covalent: strong: glycosidic bond: between c1 of the sugar and n1/n9 of the base, phosphodiester bonds: 2 ester linkages - one between o3 and o and one between o and c5. Dna is in water that will organize so to form a maximum number of h bonds. The number of h bonds will be much higher with sugars and the phosphodiester links than with the bases. Dna will organize itself so that the h bonds can be maximized due to the force created by the water. Nb: there are still some h bonds with the bases in the interior, but there are much fewer - much fewer water molecules in the centre. Water dictates the structure of the dna double helix.
