BCH 3170 Study Guide - Midterm Guide: Chromatin, To Tell The Truth, Endonuclease
16 Oct 2011
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Fundamental dogma in biology proteins, as proposed by dr. crick. Dna can also give rise to dna through replication. There are certain exceptions to this rule, such as reverse transcriptase and the rna world concept. Dna is the holder of genetic information, which is transcribed into mrna which is translated into. A proteinaceous infectious particle, misfolded versions of regular proteins. There are posttranslational modifications of the regular protein into a prion protein, which is then able to misfold other proteins. Prions are involved in peptide-mediated diseases (ex. mad cow disease). They combine to form extracellular insoluble fibrous aggregates. It is a protein-mediated infection or information transfer, therefore an exception to the central dogma. Prions are resistant to temperature increases and protease k. prions were first discovered by dr. pursiner. One biopolymer"s sequence is used as a template for the construction of another biopolymer, which has a directional flow.
