Study Guides (248,337)
Canada (121,491)
Biology (1,271)
BIO3153 (18)

Lecture 6 - EXAM VERSION.docx

4 Pages
Unlock Document

Michael Jonz

Lecture 6EXAM VERSIONNovember21121250 PM APOPTOSISApoptosisProgrammed cell deathControls number of cells total cell massDiffers from necrosis trauma or cytotoxicity leading to decrease in production and storage of ATP reduction of control of ATPases followed by lysis death by other pathways Way of removing to have little impact on surrounding tissue and cellsWhyBalance of cell division with death in adult tissues if not tissue would grow or shrinkWe make more cells that needed to make sure that appropriate connections can be made insuranceFigure mouse paw in frogs Apoptosis in developmentcells undergoing apoptosis webbed hands loss of cells between digits pronounced fingers General CharacteristicsFor apoptosis to occur cell must undergo significant biochemical and morphological changeInitiation by intracellular or extracellular signalActivation of a series of proteins involved in promoting apoptosis or inhibition of those that prevent itImportant intracellular proteins necessary for survival are cleaved during apoptosisOrderly disposal of dead cell Structural Changes during ApoptosisChromatin condenses shrinkage of cytoplasm1Nucleus fragmented1DNA ladderingBlebbing bulge of plasma membrane containing materialCell fragmentationApoptic body engulfed by phagocyte gets rid of bits and pieces of cell1loss of adhesion PhagocytosisAsymmetric distribution of plasma membrane is lost because of apoptosisNegatively charged phophatidylserine becomes exposed outside cellCell marked for phagocytosis by macrophage CaspasesProteases that cleave essential proteinsInvolved in most changes observed during cell death
More Less

Related notes for BIO3153

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.