BPS 2110 Midterm: BPS 2110 MIDTERM II REVIEW

• School: University of Ottawa
• Department: Biopharmaceutical sciences
• Course: BPS 2110
• Professor: Robert Ben

Document Summary

Explain how the degree of ionization can predict drug absorption. Explain how solubility is affected by ph. Explain the importance of the partition coefficient & chirality in drug development & formulation. Describe the 3 mechanisms of membrane transport. Discuss drug transporters classifications & transport mechanisms. Describe the tissue distribution & some functions of transporters super families. Biopharmaceutics: the study of therapeutic substances and its bioactivity, involving the preparation, use, and administration of drugs to living organisms. In vivo producing the desired therapeutic effect. It requires physicochemical considerations and physiological considerations. Drugs usually behave as weak acids and weak bases and follow the bronsted acid-base theory (a=proton donor, b=proton acceptor) Drugs are always partially ionized therefore, their ionized and un-ionized forms exist in solution: ionization and pka. Degree of ionization is dependant on the ph of the solution. To determine the relationship between ph and ionization we use the henderson-hasselbach equation.