Study Guides (248,610)
Canada (121,635)
BPS3101 (17)

Lecture 1 (exam notes).docx

4 Pages

Biopharmaceutical sciences
Course Code
Linda Bonen

This preview shows page 1. Sign up to view the full 4 pages of the document.
Lecture 1  DNARNAProtein o Transcription then translation to a protein  Genome Transcripteome proteome  Genomics- study of complete set of genes in an organism  Functional genomics- study of complete set of mRNAs (transcriptome) in cell/tissue/ organisms  Proteomics- study of complete set of proteins in cell/tissue/organism   What kind of cell is this? o Eukaryotic because of nucleus and mitochondria and because the nucleus is bound and there is a cytoskeletal properties (compartmentalization) o What kind of eukaryotic cell ISN’T it?  Plant because there is no cell wall/ vacuole/ chloroplast, this is also not a plant/ algal cell  NOTE: the chloroplasts and mitochondria have their own genomes ~  Environmental genomics (metagenomics)- study of collective genomes in an environment community ~  Human microbiome (metagenomics)- study of microbes in and on humans  Genome projects are usually large-scale collaborative efforts  “we have ten times as many microbial cells in our body as human ones and though they are tiny that still means that a 200 pound man is carrying two to six pound of microbes, mostly bacteria” ~  Personal genomics- sequence analysis of the genomes of individuals  Glen Close had her genome mapped cost is $48000, by Illumina (company leading the race in whole genome sequencing) ~  Personalized cancer genomics- sequence analysis of DNA from cancer cells  In 2012- Lukas Wartman was diagnosed with leukemia. He sequenced his genome (of cancer cells and regular cells) and his RNA (functional genomics). They found a normal gene that was in override (aberrant gene), it was producing a lot of protein that was contributing to the cancer growth  They had a kidney cancer drug that might shut down the aberrant gene, and they administered it and now his cancer is in remission ~  Pharmacogenomics- study of how human genetic makeup influences drug response o Designer drugs/ and personalized medicine  NOTE:  pharmacoGENETICS- response of drugs on SPECIFIC genes  PharmacoGENOMICS- response of drug on WHOLE GENOME  -omics generally involves a high through-put and large scale study  Personal genomics- sequence analysis of the genomes of individuals ~  Epigenomics- genome wide study of impact of chromatin structure on gene regulation  Heritable effects of DNA methylation, histone modification etc..  Ex. genetically identical mice but different methylation states ~  Metabolomics- high throughput study of metabolites (lipids, carbs, amino acids) in cell or tissue ~  Evolutionary genomics- study of genome evolution and consequences o Questions to consider:  When did resistance to malaria  Lactose tolerance/ intolerance ~  IMPORTANT**  How large is the human genome in base pairs (bp)? o 3.2
More Less
Unlock Document

Only page 1 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.