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BPS3101 (17)
Final

Lecture 1 (exam notes).docx

4 Pages
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Department
Biopharmaceutical sciences
Course Code
BPS3101
Professor
Linda Bonen

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Description
Lecture 1  DNARNAProtein o Transcription then translation to a protein  Genome Transcripteome proteome  Genomics- study of complete set of genes in an organism  Functional genomics- study of complete set of mRNAs (transcriptome) in cell/tissue/ organisms  Proteomics- study of complete set of proteins in cell/tissue/organism   What kind of cell is this? o Eukaryotic because of nucleus and mitochondria and because the nucleus is bound and there is a cytoskeletal properties (compartmentalization) o What kind of eukaryotic cell ISN’T it?  Plant because there is no cell wall/ vacuole/ chloroplast, this is also not a plant/ algal cell  NOTE: the chloroplasts and mitochondria have their own genomes ~  Environmental genomics (metagenomics)- study of collective genomes in an environment community ~  Human microbiome (metagenomics)- study of microbes in and on humans  Genome projects are usually large-scale collaborative efforts  “we have ten times as many microbial cells in our body as human ones and though they are tiny that still means that a 200 pound man is carrying two to six pound of microbes, mostly bacteria” ~  Personal genomics- sequence analysis of the genomes of individuals  Glen Close had her genome mapped cost is $48000, by Illumina (company leading the race in whole genome sequencing) ~  Personalized cancer genomics- sequence analysis of DNA from cancer cells  In 2012- Lukas Wartman was diagnosed with leukemia. He sequenced his genome (of cancer cells and regular cells) and his RNA (functional genomics). They found a normal gene that was in override (aberrant gene), it was producing a lot of protein that was contributing to the cancer growth  They had a kidney cancer drug that might shut down the aberrant gene, and they administered it and now his cancer is in remission ~  Pharmacogenomics- study of how human genetic makeup influences drug response o Designer drugs/ and personalized medicine  NOTE:  pharmacoGENETICS- response of drugs on SPECIFIC genes  PharmacoGENOMICS- response of drug on WHOLE GENOME  -omics generally involves a high through-put and large scale study  Personal genomics- sequence analysis of the genomes of individuals ~  Epigenomics- genome wide study of impact of chromatin structure on gene regulation  Heritable effects of DNA methylation, histone modification etc..  Ex. genetically identical mice but different methylation states ~  Metabolomics- high throughput study of metabolites (lipids, carbs, amino acids) in cell or tissue ~  Evolutionary genomics- study of genome evolution and consequences o Questions to consider:  When did resistance to malaria  Lactose tolerance/ intolerance ~  IMPORTANT**  How large is the human genome in base pairs (bp)? o 3.2
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