[CHM4139] - Final Exam Guide - Everything you need to know! (57 pages long)

• School: University of Ottawa
• Department: Chemistry
• Course: CHM 4139
• Professor: Roberto Chica

Document Summary

Definitions: enzyme: it"s a protein that catalyses a chemical reaction in cells. Properties of enzymes: high rate acceleration, high rate compared to anything(uncatlysed). Shows that the spontaneous rates of biochemical reactions(t1/2) range from seconds to over a billion years. Most enzymes have kcat values in the 100-1000 s-1 range. Refer to rate acceleration by enzyme handout in blackboard. That is the rate required to sustain life. Enzymes can accelerate a reaction by up to 1026 folds!! And they are the most efficient catalyst known. 1: high turnover number: how many molecules an enzyme can transform before it can no longer be used. : 1 molecule of catalyst can covert 4x107 molecules of hydrogen peroxide to oxygen each second. (just an example) Many good small molecule catalysts can convert 10-100 molecules of substrate before becoming inactive: selectivity, chemoselectivity: enzymes can discriminate between functional groups.