HSS 3106 Final: Pharmacology Final Exam Drug Notes
12 Apr 2018
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Meperidine (demerol) parenteral anesthetic; stimulate opioid receptors in gi tract to increase mixing movement of the gut and decrease peristaltic movements (treat diarrhea) More likely in older adults, constipation, nausea and vomiting, agitation, drowsiness, tachycardia, numbness of hands and feet. Intestinal obstruction and children younger than 6; not recommended for treatment of chronic diarrhea. Pt info: have them keep diary of bowel movements, advise to drink clear fluids for a few days. Treatment of diarrhea opioid-receptor agonist acts upon y-opioid receptors in myenteric plexus of large intestine; does not cross blood- brain barrier so does not affect cns. Raise ph of the stomach and decrease absorption of drugs. Anesthetic; reduce secretion of gastric acid by blocking h2 receptors (treatment of gerd); used in short term treatment of ulcers and prevention of recurrence; heartburn. Inhibit acid secretion for 6-24 hours- may improve asthmatic symptoms in people with both; rarely provide symptom relief in people with chronic gerd.
